Wild ARMS Twilight Venom follow the story of a 25 year old gunslinger, Sheyenne. He is trapped in the boyd of a 5 year old boy. Which makes things humorous for items for An ex-gun fighting. He is making a journey to get his body back. He has a few people that travel with him Kiel and Isaac, who run into many troubles. Along the way they also keep running into Loretta, Mirabelle and Jerusha.